环境危害和男性生育能力:为什么我们不知道更多?
Makiko Mitsunami1, Jaime E Hart1,2, Jorge E Chavarro2,3
1Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Seminars in reproductive medicine
|February 10, 2025
概括
大多数男性生育研究使用常见的研究设计,可能会限制对环境影响的理解. 未来的研究应该建立在这些方法的基础上,以更好地评估环境暴露和男性生殖健康.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 流行病学 流行病学
背景情况:
- 环境危害越来越多地与男性生育问题有关.
- 目前的研究主要采用特定的研究设计,这可能会阻碍全面的理解.
- 现有的文献强调了在男性生殖健康研究中需要精细的方法.
研究的目的:
- 批判性地评估环境暴露和男性生育研究中常见的研究设计策略.
- 识别流行研究方法所造成的局限性.
- 为推进该领域提出替代和互补的战略.
主要方法:
- 分析常见的研究设计特征在近期关于环境危害和男性生育能力的文献中.
- 检查招聘策略 (例如生育诊所).
- 审查暴露评估方法 (单个与多个) 和结果措施 (精液质量参数).
主要成果:
- 几乎所有研究 (97%) 使用至少三个常见设计中的一个:从生育中心招募 (53%),评估单次暴露 (87%),或仅依赖传统的精液参数 (45%).
- 这些普遍的设计虽然具有信息性,但可能会对对环境影响的全面理解造成障碍.
- 讨论了这些方法的局限性,与推进男性生育研究有关.
结论:
- 目前在男性生育研究中的研究设计虽然合乎逻辑,但可能会限制进步.
- 研究人员应该将这些设计视为起点,而不是终点.
- 采用更广泛的策略对于更全面地了解环境暴露如何影响男性生育能力和人类生殖能力至关重要.
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