大麻 - - 是朋友还是敌人?
Bianca-Maria Tihăuan1, Tatiana Onisei2, Walter Slootweg3
1Research Institute of the University of Bucharest-ICUB, 91-95 Spl. Independentei, 50567 Bucharest, Romania; National Institute for Research and Development in Food Bioresources, Dinu Vintilă Street, No.6, 021102 Bucharest, Romania; eBio-hub Research Centre, National University for Science and Technology Politehnica Bucharest, Bucharest, Romania; Academy of Romanian Scientists, Bucharest, Romania.
概括
通过皮肤输送的大麻 (CBD) 为口服途径提供了一个有希望的替代方案,克服了生物利用率低下并提高了治疗潜力. 本研究检查了系统向的皮肤输送策略,并审查了CBD的CBD.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 皮肤病学 皮肤病学
- 大麻素研究 研究 大麻素研究
背景情况:
- Cannabidiol (CBD) 是来自Cannabis sativa的衍生物,具有显著的治疗潜力,包括抗炎和抗氧化特性.
- 传统的注射途径 (例如口服) 面临着溶解性差,肝脏降解和不规则的生物可用性等挑战.
- 透皮输送系统正在成为提高CBD生物可用性和向效果的可行替代方案.
研究的目的:
- 批判性地研究大麻二醇 (CBD) 通过皮肤给药的方法.
- 探索皮肤作为系统CBD向的途径的潜力.
- 根据给药方法,提供关于CBD可变生物利用率和ADME概况的见解.
主要方法:
- 基于文献的转皮CBD输送系统的审查和分析.
- 检查增强皮肤透和系统向CBD的策略.
- 通过不同的途径收集CBD的吸收,分布,新陈代谢和分泌 (ADME) 数据.
主要成果:
- 通过皮肤递送系统是克服传统CBD管理局限性的有希望的策略.
- 皮肤提供了有针对性的全身传递的潜力,与口服途径相比,提高了生物可用性.
- 由于CBD的生物可用性受到注射途径和配方的显著影响,因此需要进一步研究.
结论:
- 通过皮肤给予CBD是一种可行的方法,可以提高治疗效果,克服生物可用性挑战.
- 由于不断变化的监管环境和不断增长的市场,进一步的临床研究和标准化配方至关重要.
- 了解内分泌系统和CBD的相互作用是优化其在不同疾病中的治疗应用的关键.
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