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粉纳米晶体的氧化和碳氧甲基化:结晶结构,分散性,分散稳定性和蛋白质加载效率研究
Wen-Xuan Hu1, Liang-Sen Liao1, Le Shi1
1College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, PR China.
International journal of biological macromolecules
|February 10, 2025
概括
使用氧化和碳甲基化对粉纳米晶体 (SNC) 的表面修饰提高了它们的分散性,稳定性和蛋白质加载能力. 这些增强的SNC显示出更广泛的工业应用的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物化学 生物化学
背景情况:
- 粉纳米晶 (SNC) 是有前途的纳米材料,但它们在水溶液中的聚合限制了应用.
- 提高SNC的分散性和稳定性对于它们的有效利用至关重要.
研究的目的:
- 提高SNCs的分散性,稳定性和蛋白质载荷能力.
- 研究氧化和碳甲基化对SNC特性的影响.
主要方法:
- 粉纳米晶体通过氧化和碳基甲基化进行了修改.
- 使用FT-IR,XPS和NMR光谱学证实了表面修饰.
- 评估了物理化学性质,包括分散性,稳定性和蛋白质负载.
主要成果:
- 氧化和碳氧甲基化成功地改变了SNC表面,增强了分子间静电排斥.
- 修改后的SNC (OSNC和CSNC) 显示出更好的分散性,稳定性 (尤其是低pH下的OSNC) 和结构紧性.
- OSNC和CSNC都表现出增强的蛋白质负载能力,OSNC显示出更高的潜力.
结论:
- 氧化和碳素甲基化是通过减少聚合来提高SNC的分散性和稳定性的有效策略.
- 由于增强的载荷能力,修改后的SNC提供了作为蛋白质输送载体的潜力.
- 这些修改扩大了粉纳米晶的工业应用.
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