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Updated: May 28, 2025

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

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断裂融合桥循环驱动高瘤基因数量与中度的瘤内异质性

Siavash Raeisi Dehkordi1, Ivy Tsz-Lo Wong2,3, Jing Ni4,5

  • 1Department of Computer Science and Engineering, University of California San Diego, San Diego, CA, USA.

Nature communications
|February 10, 2025
PubMed
概括

断裂融合桥 (BFB) 循环和染色体外DNA (ecDNA) 通过增加瘤基因拷贝数量来驱动癌症. 我们的新算法OM2BFB检测到BFB放大,揭示了与ecDNA相比不同的生物特征和治疗潜力.

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