类风湿性关节炎与间歇性肺病之间的关联以及血清状况的影响:一项大型纵向研究
Bo-Guen Kim1,2, Hyun Lee2, Yeonghee Eun3
1Division of Pulmonary Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Scientific reports
|February 10, 2025
概括
患有类风湿性关节炎 (RA) 的人面临患间歇性肺病 (ILD) 的风险明显更高. 即使在血清阴性RA患者中,这种风险也较高,这凸显了需要警监测的必要性.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 与较差的患者结局有关,特别是当由间歇性肺病 (ILD) 复杂时.
- 大规模的纵向数据比较RA中的ILD发病率与非RA人群的ILD发病率是有限的.
- 了解与RA血清状况相关的特定风险对于患者管理至关重要.
研究的目的:
- 为了比较患有RA的个体中发展ILD的发病率和风险,与匹配的非RA队列相比.
- 评估类风湿性关节炎的血清状况 (血清阳性与血清阴性) 如何影响发生ILD的风险.
- 在RA患者中为ILD提供临床监测策略的信息.
主要方法:
- 一项基于人口的大规模队列研究,使用2010-2017年韩国国家医疗保险服务数据.
- 包括52325名RA患者和261625名没有RA的匹配对照.
- 平均随访时间为4.4年,以确定发生的ILD诊断.
主要成果:
- 与对照组相比,ILD的发病率在RA队列中显著更高 (8.30/1,000人年),而对照组 (1.01/1,000人年).
- 关节炎患者的发生性ILD风险显著增加 (调整后危险比率[aHR]7.84).
- 与对照组相比,血清阳性RA (aHR 9.00) 和血清阴性RA (aHR 4.81) 均显示ILD风险增加,血清阳性RA的风险高于血清阴性RA.
结论:
- 类风湿性关节炎显著增加患间歇性肺病的风险.
- 即使是患有血清阴性RA的个体,与一般人群相比,他们也面临着相当高的ILD风险.
- 在所有RA患者中,对ILD进行密切监测是有必要的,包括那些血清阴性患者.
更多相关视频
相关概念视频
Genome-wide Association Studies-GWAS
12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.3K
The JAK-STAT Signaling Pathway
8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.6K
Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
Other Pulmonary Disorders
798
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
798
Pulmonary Tuberculosis II
211
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
211
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K


