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在胸腔镜分管切除术期间进行一次肺呼吸会改变肺微生物组的多样性和组成
Zhang Ruijiao1, Li Tianyuan1, Wu Shiyin1
1Department of Anesthesiology and Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, 330001, China.
Scientific reports
|February 10, 2025
概括
一肺通风 (OLV) 在手术期间改变了肺微生物组,增加了像Ralstonia.com这样的特定细菌. 这种转变与炎症标志物升高相关,这表明微生物变化和肺损伤之间存在联系.
科学领域:
- 肺部医学 肺部医学
- 微生物学 微生物学
- 手术研究的研究.
背景情况:
- 肺部拥有独特的微生物组,可以通过机械通风来破坏.
- 单肺通风 (OLV) 可能导致缺血-再输液 (IR) 损伤,导致术后急性肺损伤.
- 了解OLV期间肺微生物组的变化对于管理手术肺部并发症至关重要.
研究的目的:
- 在胸腔镜叶切除术期间进行单肺通风后,研究肺微生物组的变化.
- 评估改变的肺微生物群对炎症反应的影响,特别是IL-1β和TNF-α水平.
- 为了确定与OLV后的炎症变化相关的特定微生物种群.
主要方法:
- 对65名接受胸腔镜叶切除术的患者进行前性研究.
- 在OLV之前和之后收集的支气管支气管洗液 (BALF) 的对分析.
- 微生物组成分析和IL-1β和TNF-α水平的量化.
主要成果:
- 在OLV后观察到包括Veillonella,Rothia,Ralstonia和Melittanglum在内的特定细菌的丰度发生显著变化.
- 总体而言,微生物多样性和α多样性保持不变.
- IL-1β和TNF-α的水平在OLV后显著增加,Ralstonia的丰度与这些炎症标志物有积极的相关性.
结论:
- 一个肺的通风显著改变肺微生物组合在胸腔镜分泌过程中.
- 在OLV后增加Ralstonia丰度与炎症反应 (IL-1β,TNF-α) 的增加有关.
- 这些发现突显了肺微生物组在OLV后调解炎症中的作用,并表明了潜在的治疗点.
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