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Updated: May 28, 2025

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药理上的CDK4/6抑制促进乳腺癌中对 lysosomotropic 药物的脆弱性

Jamil Nehme1, Sjors Maassen1, Sara Bravaccini2

  • 1European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands.

The EMBO journal
|February 10, 2025
PubMed
概括

这项针对耐药乳腺癌的研究表明,循环素依赖性激酶4/6抑制剂 (CDK4/6i) 会增加 lysosomal 质量. 这使得癌细胞易受 lysosomotropic 药物影响,提供了一种新的序列治疗方法.

关键词:
阿贝马西克利布 (Abemaciclib) 是一个有着CDK4/6 抑制剂 抑制剂 CDK4/6 抑制剂细胞衰老 细胞衰老lysosome 是一个溶解体.p16 p16 在这个问题上.

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