协调的基因表达和荷尔蒙流动决定了Panax notoginsengeng花的花发育中的金氏酸Rb3生物合成
Can Wang1, Hongwei Sun1, Yuling Yang1
1Wenshan Academy of Agricultural Sciences, Wenshan, 663000, Yunnan, China.
BMC plant biology
|February 10, 2025
概括
芽阶段对于Panax notoginseng (PN) 中的金丝诺化物Rb3的产生至关重要. 参与类生物合成的关键基因和转录因子在这个阶段表现出增加的活动,揭示了关键的分子通路.
科学领域:
- 植物生物化学 植物生物化学
- 分子生物学分子生物学
- 药品化学 药品化学 是一个
背景情况:
- 帕纳克斯诺托金生 (Panax notoginseng,简称PN) 是一种重要的药用草本.
- 银化物,特别是Rb3,是PN中关键的治疗化合物.
- 了解金氏化物生物合成对于其药用应用至关重要.
研究的目的:
- 为了研究PN花中的金色化物Rb3生物合成的分子机制.
- 确定影响Rb3生产的关键发育阶段和监管因素.
- 阐明涉及到金氏化物合成的特定生化途径.
主要方法:
- 转录组分析以评估基因表达转移.
- 基因组丰富分析 (GSEA) 用于识别上调的途径.
- 激素水平与转录因子活性的相关性.
- 生物合成路径的重建.
主要成果:
- 芽阶段 (T2) 被认为是提高Rb3生产的关键阶段.
- 在T2.2观察到的二次代谢产生的基因显著上调,类生物合成和修改途径.
- 梅瓦酸途径主导着金氏化物生物合成.
- 关键酶 (ACAT,PPDS,DDS,LUP4) 和转录因子 (MYC2,MYB124,MYB61.1) 在T2.2时表现出峰值活性.
结论:
- 详细了解了在PN中调节人参化物生物合成的基因网络.
- 识别芽阶段是生殖基因化物生产的关键时期.
- 这些发现有助于理解和潜在地增强PN的药用特性.
相关概念视频
Cell Signaling in Plants
5.6K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.6K
Combinatorial Gene Control
8.3K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.3K
Morphogenesis
25.2K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
25.2K
Cell Specific Gene Expression
13.4K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.4K
Diversity in Cell Signaling Responses
6.3K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
6.3K
Regulation of Expression at Multiple Steps
864
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
864


