转录因子XBP1s通过向MAP3K2,这是MAPK/ERK通路中的关键基因,从而促进子宫内膜炎诱导的上皮质-介质细胞过渡

Kangkang Gao1,2, Mengqi Si1,2, Xinxi Qin1,2

  • 1Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.

概括

转录因子X盒结合蛋白1拼接变体 (XBP1s) 通过调节MAP3K2和激活MAPK/ERK通路来驱动子宫内膜炎诱导的上皮质-介质细胞过渡 (EMT). 抑制XBP1s或MAP3K2可以减少EMT和细胞迁移.

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