牙脱落后口腔微生物群的转移会影响肠道健康
Ling Dong1, Zhaoxin Ji1, Jiangqi Hu1
1Department of Prosthodontics, School of Stomatology, Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China.
BMC oral health
|February 10, 2025
概括
失去牙显著改变了小鼠的口腔和肠道微生物群,影响了微生物平衡. 这些发现表明,在失去牙后,对人类肠道健康有潜在的影响.
科学领域:
- 微生物学 微生物学
- 口腔健康 口腔健康
- 肠道健康 肠道健康
背景情况:
- 失去牙会损害口腔功能,并通过改变宿主微生物群影响肠道健康.
- 了解口腔肠轴对于牙损失后的全身健康影响至关重要.
研究的目的:
- 研究牙脱落对口腔和肠道微生物群组成及其相互关系的影响.
- 探索与口腔肠轴干扰相关的潜在系统性健康影响.
主要方法:
- 采用了一种小鼠模型 (C57小鼠) 进行了骨提取.
- 分析了口腔和肠道微生物群的变化,使用16S rRNA和唾液和便样本的元基因组测序.
- 通过皮尔森相关性分析评估微生物社区关系.
主要成果:
- 失去牙导致口腔微生物群的多样性减少,蛋白质菌增加,菌减少.
- 肠道微生物群呈现出Firmicutes的增加和Bacteroidota的减少.
- 观察到口腔和肠道微生物群变化之间的相关性,表明牙脱落和肠道微生物不平衡之间存在联系.
结论:
- 在小鼠模型中,失去牙会破坏口腔肠道微生物群的平衡,这可能会对肠道健康产生潜在影响.
- 研究结果表明,鉴于已建立的口腔-肠轴,在失去牙后,人类肠道微生态需要注意.
- 进一步的研究可能会阐明牙脱落对人类肠道健康和全身健康的直接影响.
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