加快的生物衰老调解了炎症标记与Helicobacter pylori感染和死亡率之间的关联
Jiayu Qiu1,2,3, Hui Fang4, Dingwei Liu1,2,3
1Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Journal of translational medicine
|February 10, 2025
概括
杆菌感染增加死亡风险,与炎症和加速生物衰老有关. 在H. pylori阳性个体中炎症标志物升高可能会通过生物衰老机制导致死亡.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 杆菌 (H. pylori) 感染是一个全球性的健康问题.
- 系统性炎症与各种慢性疾病和死亡率有关.
- 生物衰老是影响疾病结果的潜在因素.
研究的目的:
- 研究H. pylori感染个体的全身炎症和死亡率之间的关联.
- 确定加速生物衰老是否介导着H. pylori感染和死亡率之间的关系.
主要方法:
- 使用NHANES 1999-2000数据从3509名美国参与者的横截面研究.
- 使用了卡普兰-梅尔生存分析,考克斯回归,K-means集群和调解分析.
- 探索炎症标志物,生物衰老 (PhenoAgeAccel),H. pylori状态和全因死亡率之间的关系.
主要成果:
- 血清阳性H. pylori参与者表现出明显更高的全因死亡率 (P < 0.001).
- 炎症增加与H. pylori阳性个体 (P < 0.001) 的PhenoAgeAccel和死亡率有关.
- 炎症标志物 (中性粒细胞计数,SIRI) 通过PhenoAgeAccel显示出对死亡率有显著的间接影响 (介导49-50%).
结论:
- 血中炎症标志物升高与H. pylori感染中全因死亡风险增加有关.
- 加快的生物衰老可能是这种关联背后的关键生物机制.
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