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Updated: Jun 14, 2026

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions
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通过对药物-纳米晶体相互作用的多层次探索,潜入功能性金属氧化物的表面

Nicolò Maria Percivalle1, Julia Blandine Bassila2, Alice Piccinini3

  • 1Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.

ACS applied materials & interfaces
|February 11, 2025
PubMed
概括

这项研究开发了优化氧化纳米晶体 (ZnO NCs),用于向药物输送. 计算建模和实验改善了对多发性骨髓瘤治疗中卡菲尔佐米布 (CFZ) 的纳米载体设计.

关键词:
卡菲尔佐米比 (Carfilzomib) 是一种药物.粗粒度模型是粗粒度的模型.药物输送是药物输送的过程.分子动力学模拟,分子动力学模拟小角X射线散射的小角度X射线散射.表面功能化的功能化.氧化氧化的使用方法

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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...