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纳普罗酶体的电位传感器基于用化修改的糊电极 ((II) 复杂的复杂

Rufina A Zilberg¹, Julia B Teres¹, Ivan V Vakulin¹

¹Institute of Chemistry and Protection in Emergency Situations, Ufa University of Science and Technology, Ufa, Russian Federation.

|February 11, 2025

概括

一个新型的enantioselective电压测量传感器使用修改的碳黑糊电极,可以选择性地检测纳普洛克森 enantiomers. 这种传感器在各种复杂矩阵中提供高灵敏度和准确度的纳普 (Nap) 测定.

科学领域:

电分析化学电分析化学
材料科学材料科学材料科学
药品分析药品分析

背景情况:

纳普罗 (Nap) 是一种广泛使用的非类固醇抗炎药物 (NSAID).
药品的反体纯度对于有效性和安全性至关重要.
开发选择性传感器,用于治疗性药物分析是必不可少的.

研究的目的:

开发一种新型的enantioselective电压测量传感器 (EVS) 用于区分和量化纳普洛克森反体.
调查传感器的性能特征,包括选择性,灵敏度和检测极限.
为了验证传感器在现实世界样本中的适用性,例如生物流体和制药配方.

主要方法:

一个碳黑糊电极 (CBPE) 的制造,该电极经过合性Ni (II) 复合物的修改.
使用SEM,EDS-SEM,FT-IR,EIS和CV进行表征.
使用微分脉冲电压测量 (DPV) 电化学测定纳普洛克森反体.

主要成果:

该CBPE@(S) -Ni传感器对 (S) -Nap比 (R) -Nap具有很好的选择性.
对于 (S) - Nap,观察到高灵敏度,为两个反体建立了线性范围.
准确确定混合物,生物流体和药物形式中的纳普罗反体,具有低RSD和高回收.

结论:

开发的EVS是一个有前途的工具,用于选择性和敏感的纳普罗反体的电化学测定.
该传感器在复杂矩阵中表现出卓越的性能和适用性.
这项工作有助于在制药分析中推进奇拉感应技术.

关键词:

碳黑碳黑是一种合性Ni (II) 复合体体识别体识别体识别体传感器的感应器纳普罗森的反体是纳普罗森的反体.粘贴电极电极是一种粘贴电极.电压测量是一种电压测量.

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