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Updated: May 28, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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对MuRF1-UBE2复合物的结构预测确定了每个MuRF1-E2对相互作用选择性的氨基酸残留物

Agnès Claustre1, Mélodie Malige1, Maëlys Macheton1

  • 1Université Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, France.

The FEBS journal
|February 11, 2025
PubMed
概括

肌肉缩E3联酶MuRF1与四个E2酶相互作用,通过计算和实验方法揭示了不同的接口. 了解这些相互作用可能会导致肌肉消耗疾病的新疗法.

关键词:
在 MuRF1/TRIM63 中使用.环型E3结合酶是指环型E3结合酶.在 UBE2 中,UBE2 是蛋白蛋白相互作用的选择性 选择性在任何地方都是无处不在的.

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