马转交替电流刺激对人类运动皮质产生频率依赖的效果 泰达爆发刺激诱导的可塑性
Wei-Yeh Liao1, Brodie J Hand1, John Cirillo1
1Discipline of Physiology, School of Biomedicine, University of Adelaide, Adelaide, Australia.
The European journal of neuroscience
|February 11, 2025
概括
超交替电流刺激 (tACS) 的高马频率 (90 Hz) 结合间歇性甲爆刺激 (iTBS) 增强了初级运动皮层中的长期强化 (LTP) 类似的可塑性 (M1). 这种特定频率的神经可塑性增强在运动唤起的潜能中被观察到,但不是短间隔的皮质内抑制.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 大脑刺激 大脑刺激
背景情况:
- 间歇性甲爆刺激 (iTBS) 在主运动皮层 (M1) 中诱导长期强化 (LTP) 类似的可塑性.
- 在马频率的跨交替电流刺激 (tACS) 可以调节这种可塑性,之前的研究表明70 Hz频率是最佳的.
- 有证据表明,对于tACS对运动功能的影响,频率特异性在马频段中 (60-90 Hz) 内.
研究的目的:
- 研究不同马波段tACS频率 (60,75,90赫兹) 对iTBS诱导的神经可塑性的影响.
- 为了确定特定的马频率是否增强了运动皮层对iTBS的反应.
主要方法:
- 17名健康的年轻人参加了四次实验性会议.
- 采用了tACS-iTBS辅助刺激方法,将iTBS应用于M1上,并与假或60,75或90赫兹tACS相结合.
- 经磁刺激 (TMS) 评估了运动唤起潜力 (MEP) 幅度和短间隔皮质内抑制 (SICI) 后后前 (PA) 和前后后 (AP) 线圈方向在干预前后.
主要成果:
- 与假装的tACS相比,使用90 Hz马tACS的成本刺激显著增加了PA和AP MEP振幅,而60 Hz和75 Hz则没有.
- 通过tACS-iTBS共刺激,无论马tACS频率如何,PA和AP SICI都被减少了.
- 在测试的最高马频率 (90 Hz) 中,观察到LTP类可塑性的最大增强.
结论:
- 马tACS,特别是在更高的频率 (90赫兹),可以增强iTBS诱导的LTP类可塑性在主要运动皮质.
- 马tACS的频率在调节运动皮层可塑性方面起着至关重要的作用.
- 需要进一步的研究来探索针对不同大脑区域和人群中更高马频率的功能相关性.
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