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对于c-Met向PET成像的Ga-标记SL1Aptamer进行68的临床前评估

Xuwei Liu^{1,2,3,4,5,6,7}, Yamei Chen⁸, Fengsheng Zhang^1,2,3,4,5,6

¹Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.

Molecular pharmaceutics

|February 11, 2025

概括

一个新的aptamer成像探针,[68Ga]Ga-NOTA-SL1,成功地准和图像表达c-Met受体氨酸激酶的瘤. 这项发展为异常c-Met表达的癌症提供了改进的诊断,包括非小细胞肺癌和结直肠癌.

科学领域:

分子成像学分子成像学
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

受体氨酸激酶c-Met的异常表达在各种癌症中很常见.
开发用于c-Met的特定成像探针对于增强癌症诊断至关重要.
向c-Met有助于了解瘤进展和治疗反应.

研究的目的:

设计和制造一种基于aptamer的新型分子成像探头,针对c-Met.
评估探头在体外和体内成像c-Met阳性瘤的疗效.
在临床前癌症模型中评估探针的诊断潜力.

主要方法:

合成和特征的aptamer分子成像探测器 [68Ga]Ga-NOTA-SL1.1.
在c-Met的体外稳定性和亲和力的评估.
在瘤携带小鼠模型中体内微位子发射断层扫描/计算机断层扫描 (微PET/CT) 成像.
检测器准的免疫组织化学 (IHC) 验证.

主要成果:

[68Ga]Ga-NOTA-SL1探头具有高放射性化学纯度和良好的体外稳定性.
微PET/CT成像在具有不同c-Met表达的模型中显示出有效的瘤吸收和可视化.
定量分析显示,HCC827,PC-9和HCT116模型中的瘤吸收显著.
IHC证实了探测器对c-Met的特定分子病理向.

结论:

开发的[68Ga]Ga-NOTA-SL1探针有效地对c-Met阳性瘤进行成像.
该探测器在非小细胞肺癌和结直肠癌模型中表现出良好的新陈代谢和准性能.
这种基于aptamer的成像剂在改善异常c-Met表达的癌症的诊断方面显著有前途.

关键词:

一个aptamer的应用程序.在c-Met Met中使用.分子成像分子成像技术有针对性的成像成像.

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