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Ce 单个原子具有级联自循环酶类活动和用于癌症治疗的光热活动

Jialiang Guo¹, Mengdie Jin¹, Yongkang Huang¹

¹Tianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering & National Institute for Advanced Materials, Nankai University, Tianjin, 300350, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)

|February 11, 2025

概括

单原子纳米酶 (Ce SAs) 表现出多种类似酶的活动和光热特性,用于协同瘤治疗. 这种新的方法通过向瘤微环境 (TME) 来提高治疗效率.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

针对瘤微环境 (TME) 对于有效的癌症治疗至关重要.
现有的对TME敏感的纳米酶因基质可用性有限而面临局限性,影响治疗结果.
开发具有增强催化和治疗功能的新型纳米酶是必不可少的.

研究的目的:

为增强瘤治疗合成和表征单原子纳米酶 (Ce SAs).
调查Ce SAs在TME中的级联自我循环酶类活动.
评估Ce SAs酶活性和光热性质的联合治疗潜力.

主要方法:

(Ce) 经过使用热性伊米达酸框架-8 (ZIF-8) 来固定,以制备Ce SAs.
评估了Ce SAs的类似酶的活动 (氧化酶,氧化酶,催化酶,葡萄糖氧化酶,谷甲氧化酶).
光热疗法 (PTT) 使用808nm近红外 (NIR) 辐射进行.

主要成果:

Ce SAs证明了可逆的Ce3+/Ce4+转化,使多种类似酶的活动成为可能.
这些活动促进了级联自我循环,增强了TME的治疗潜力.
Ce SAs对PTT表现出显著的光热特性,导致有效的瘤细胞治疗.

结论:

通过结合级联酶活性和光热效应,Ce SAs提供了一个有希望的协同治疗策略.
开发的Ce SAs通过有效调节TME,显示了先进瘤治疗的巨大潜力.
这项研究强调了单原子纳米酶在癌症治疗中的多功能性.

关键词:

纳米酶催化疗法是一种催化疗法.光热的光热系统稀土是一种稀土.瘤微环境是一个微环境.

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