基于纤维素的生物活性材料和黄浸的柔性和生物相容的脚手架用于骨组织工程应用
Shital S Shendage1, Kranti Kachare1, Kajal Gaikwad2
1Green Nanotechnology Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, India. avg_chem@unishivaji.ac.in.
Journal of materials chemistry. B
|February 11, 2025
概括
研究人员使用回收的米和蛋开发了一种新的骨架. 这种环保材料具有出色的生物相容性,促进骨再生,为骨组织工程提供可持续的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
- 再生医学是一种再生医学.
背景情况:
- 目前的骨缺陷治疗方法,如金属植入物,自体移植和异体移植都有局限性.
- 越来越需要具有成本效益,环保和可定制的骨架,具有最佳的孔隙性和机械性能.
- 利用生物废物进行支架合成对于减少环境污染和生产成本至关重要.
研究的目的:
- 为骨组织工程开发一个可持续和生物活性的支架.
- 使用回收的米和蛋合成酸盐生物活性物质 (70S30C).
- 将生物活性物质和黄粉浸到基于纤维素的棉织物上,以提高性能.
主要方法:
- 通过使用大米皮和蛋通过沉合成70S30C生物活性物质 (BM).
- 在纤维素织物 (CF) 上浸的BM和黄粉 (Tm).
- 使用UV-Vis,XRD,FTIR,SEM,EDS对支架进行了特征化;进行了体外生物活性,降解和血液溶解研究;进行了ex ovo CAM测定和体内生物相容性和骨质生成评估.
主要成果:
- 鉴定证实了脚手架的性能.
- 在体外研究显示出良好的生物活性,降解和<5%的血液溶解 (血红相容性).
- 外卵CAM测定表明新血管化;体内研究证实无毒性,骨再生能力和抗菌性质.
结论:
- 用生物活性物质和黄浸的纤维素织物支架是骨组织工程的一个有希望的,具有成本效益和环保的选择.
- 开发出来的脚手架表现出理想的多孔性,灵活性,生物活性,可降解性,血液相容性,骨质生成和抗菌性质.
- 这种方法为治疗骨缺陷提供了一个可持续的解决方案,利用生物废物材料.
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