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Updated: May 28, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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特定于imatinib诱导的BCR-ABL突变的T细胞受体,用于采用T细胞治疗

Meng-Tung Hsu1, Gerald Willimsky2,3,4, Leo Hansmann2,3,4,5

  • 1Molecular Immunology and Gene Therapy, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Frontiers in immunology
|February 11, 2025
PubMed
概括

研究人员在慢性髓性白血病 (CML) 中鉴定了一种来自突变的BCR-ABL (ABL-E255V) 的新表位. 他们开发了针对这种突变的CML细胞的T细胞受体 (TCR),为TKI抗性CML提供了一种新疗法.

关键词:
T细胞受体受体的 T 细胞受体.慢性骨髓性白血病 慢性骨髓性白血病伊马替尼布 (Imatinib) 的使用情况新抗原是一种新抗原.电阻的阻力可以

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