在非洲实施WHO-GLASS关于优先病原体抗生素敏感性测试的建议的进展:范围审查
Mackline Hope1, Reuben Kiggundu1, Dickson Tabajjwa1
1Infectious Diseases Institute, Makerere University, Kampala, Central Region, Uganda.
Wellcome open research
|February 11, 2025
概括
世界卫生组织 世界卫生组织
科学领域:
- 全球卫生安全 全球卫生安全
- 传染病监测 传染病监测 传染病
- 抗微生物耐药性 (AMR) 是一种
背景情况:
- 世界卫生组织的全球抗菌素耐药性监测系统 (GLASS) 成立于2015年.
- 评估非洲GLASS的实施对于了解AMR监测进展至关重要.
- 关于非洲国家采用GLASS的程度的数据有限.
研究的目的:
- 进行范围审查,评估世卫组织2015年GLASS手册在非洲的实施进展.
- 确定符合GLASS关于优先样本,病原体和病原体-抗生素组合的建议的程度.
主要方法:
- 在MEDLINE和Embase数据库中使用MeSH术语进行了全面的文献搜索.
- 包括2016年1月至2023年12月以英语出版的来自非洲国家的文章.
- 数据提取遵循了Arksey和O'Malley对范围审查的方法框架.
主要成果:
- 选择了147篇文章,其中78.9%发表于2020-2023年期间,57.8%来自东非.
- 大多数研究都集中在单一优先样本类型 (血液,尿液,便) 上,报告了诸如大肠杆菌和肺炎菌等常见病原体.
- 没有研究报告测试了所有推的WHO GLASS病原体-抗生素组合.
结论:
- 在非洲实施世卫组织GLASS建议的进展是显而易见的.
- 然而,各国采用数据的显著差异阻碍了数据的标准化和可比性.
- 需要进一步努力,以确保在整个非洲大陆进行全面和一致的AMR监测.
相关概念视频
Healthcare Associated Infections II: Preventive Measures
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Urine Studies II: Urine Culture and Sensitivity Test
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
Antimicrobial Effectiveness
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...


