中国患者的系统性免疫炎症指数和结直肠多体之间的反转U形关联:一个横截面研究
Jie Bao1, Yajie Teng1, Yingxue Yang1
1Department of Gastroenterology, First People's Hospital of Kunshan, Kunshan, China.
Frontiers in medicine
|February 11, 2025
概括
系统性免疫炎症指数 (SII) 在中国患者中显示了与结直肠聚体 (CPs) 的反向U形关系. 监测SII可能有助于预测聚的发展.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 系统性免疫炎症指数 (SII) 与各种疾病有关.
- 了解SII在结直肠多瘤 (CPs) 中的作用对于早期检测和管理至关重要.
研究的目的:
- 调查SII与中国人口中CP的流行程度之间的关联.
- 探索SII作为CP的预测标记物的潜力.
主要方法:
- 一项横截面研究分析了2018年至2022年期间接受结肠镜检查的3028名中国患者的数据.
- 患者特征和SII值在具有腺瘤多体,非腺瘤多体和没有多体的组之间进行了比较.
- 统计分析评估了SII和CP存在之间的关系,包括调整的赔率比率和置信区间.
主要成果:
- 在SII (Ln-SII) 和CP流行率的自然对数之间发现了反转的U形关系.
- Ln-SII与腺瘤多瘤有显著的相关性 (OR=0.76,p=0.0003).
- 对于Ln-SII,特定的切断点表明风险在5.78以下增加,风险在5.78以上降低,在多类型中,两种情景的赔率比率均为显著.
结论:
- 这项研究揭示了Ln-SII与结直肠息肉风险之间的反转U形关联.
- 监测SII可能与评估结直肠聚的发展有关.
- 作为结直肠多瘤的预测生物标志物,SII显示出前景.
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