阻塞性气道疾病的计算表型:一个系统的审查
Muwada Bashir Awad Bashir1, Gregorio Paolo Milani2,3, Valentina De Cosmi4,5
1Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Journal of asthma and allergy
|February 11, 2025
概括
这一系统性审查突出了阻塞性呼吸道疾病计算表型的变化. 不一致的方法和缺乏可复制性阻碍了对喘,COPD和相关疾病的可靠表征.
科学领域:
- 计算生物学和生物信息学应用于呼吸系统医学.
- 数据科学和医疗保健中的机器学习.
背景情况:
- 计算方法对于表征阻塞性气道疾病表型至关重要.
- 由于方法上的差异,比较表型研究很困难.
- 无监督计算方法在呼吸道疾病研究中越来越多地使用.
研究的目的:
- 系统地审查使用无监督计算方法进行的研究,以表型化儿童和成人阻塞性呼吸道疾病.
- 描述在呼吸道疾病表型化中使用的种群,变量和计算方法.
- 识别当前计算表型化实践中的挑战和不一致性.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Scopus,Web of Science,Google Scholar) 进行系统的文献搜索 (2010-2020年).
- 包括会议记录,参考清单和专家建议.
- 独立的选,数据提取和质量评估由两名审查员进行,分歧由第三方解决.
- 综合证据,重点关注人口,变量和计算方法.
主要成果:
- 审查了120项研究:60例喘,19例严重喘,28例COPD,4例喘-COPD重叠 (ACO),9例鼻炎.
- 根据疾病的表型有所不同:喘 (形,发病年龄,严重程度),严重的喘 (症状,形,发病年龄),慢性肺炎 (肺功能,吸烟,并发症).
- 层次聚类是最常见的方法;隐性类模型,混合模型和因子分析也被使用.
- 变量报告的全面性是关键质量指标;可重复性措施往往缺乏.
结论:
- 在喘,COPD,ACO和鼻炎研究中的表型方法,参与者资料和变量中存在显著的异质性.
- 缺乏可复制性测量阻碍了对呼吸道疾病中的计算表型的评估.
- 对结果定义和变量选择的标准化方法对于可靠的呼吸道疾病表型化至关重要.
相关概念视频
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
Chronic Obstructive Pulmonary Disease
1.1K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.1K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
Chronic Obstructive Pulmonary Disease-I: Introduction
2.7K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.7K
Other Pulmonary Disorders
798
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
798
Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K


