口的中国儿童的大脑解剖学差异:一项初步研究
Dan Ma1,2, Lingling Wang1,2, Sai Liu2,3
1Department of Rehabilitation Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in neurology
|February 11, 2025
概括
儿童发育性口吃与右回和小脑灰色质量减少有关. 这些大脑结构的变化可能会为DS的未来临床治疗提供信息.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 语音和语言病理学 语言病理学
背景情况:
- 发育性口吃 (DS) 背后的神经机制在很大程度上是未知的.
- 了解口儿童的大脑结构的变化对于识别潜在原因至关重要.
研究的目的:
- 为了研究发育性口吃的中国儿童的结构性大脑形态变化.
- 分析自语的儿童与其典型发育的同龄人之间灰质体积和皮质形态的差异.
主要方法:
- 采用了一种病例控制研究设计.
- 从108名儿童中收集了磁共振成像 (MRI) 数据 (54名口吃,54名对照).
- 进行了全脑灰质体积和皮质形态分析.
主要成果:
- 与对照人群相比,口吃的儿童在右旋和双边小脑中呈现明显下降的灰质体积.
- 在吃的儿童的右侧胰岛和右上旋中观察到皮层的显著减少.
- 在右小脑和右旋中灰质体积与口吃的严重程度相关.
结论:
- 这些发现表明,发育性口吃与皮质-基底 - - 乳头-皮质循环和背部语言通路内的结构性大脑变化有关.
- 这些神经解剖学发现为了解DS的神经基础提供了基础.
- 预计这些结果将为发育性口吃的临床治疗提供有价值的见解.
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