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Updated: May 28, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

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对USP18的ISG15依赖性稳定是必要的,但不足以调节人类的I型干扰素信号

Andri Vasou1, Katie Nightingale2, Vladimíra Cetkovská1

  • 1Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews, UK.

European journal of immunology
|February 11, 2025
PubMed
概括

干扰素 (IFN) 信号由IFN刺激的基因15 (ISG15) 严格控制. ISG15通过要求与USP18进行非共价相互作用来抑制I型IFN信号传输,以实现其调节功能.

关键词:
在ISG15中,我们可以看到ISG15.第I类型的IFN信号系统.USP18 美元自发炎性疾病自发炎性疾病.这是一种干扰性异常疗法.干扰素刺激的基因是干扰素刺激的基因.

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