建平建德配方在调节CRC微环境中的作用
Mengyao Li1, Dongming Hua1, Yuanyuan Feng1
1Department of Oncology, Institute of Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Combinatorial chemistry & high throughput screening
|February 11, 2025
概括
皮吉杜食谱 (JPJDR) 通过调节瘤微环境中的免疫和层细胞来调节结直肠癌 (CRC). 这种传统中医药降低了HMGB1和MT2A的调节,可能会调节其抗瘤作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统中国医学 (TCM) 通过调节瘤微环境来表现出抗瘤特性.
- 江皮吉杜食谱 (JPJDR) 提高了结肠直肠癌 (CRC) 患者的化疗疗效率和患者的生活质量.
- 在CRC中JPJDR的精确治疗机制需要阐明.
研究的目的:
- 研究JPJDR在结肠直肠癌中的治疗效果背后的分子机制.
- 在CRC瘤微环境中识别JPJDR调节的特定细胞类型和生物过程.
- 探索HMGB1和MT2A在JPJDR反CRC活动中的潜在作用.
主要方法:
- 来自JPJDR草药的活性化合物使用HIT2.0和HERB数据库进行了鉴定.
- 分析了来自结肠直肠癌患者的单细胞RNA测序数据.
- 使用Reactome数据库进行了路径丰富分析.
- 由JPJDR诱导的基因表达变化使用RT-qPCR进行了验证.
主要成果:
- JPJDR影响免疫相关的过程,如细胞因子信号传递,细胞增殖,细胞亡和衰老.
- 在CRC微环境中,JPJDR调节多样化的细胞群,包括恶性细胞,免疫细胞 (T细胞,B细胞,髓状细胞) 和树突细胞 (纤维细胞,内皮细胞).
- 在结肠直肠癌中,JPJDR显著降低了HMGB1和MT2A的表达.
结论:
- JPJDR通过调节结肠直肠癌微环境中的各种细胞类型来发挥其作用.
- HMGB1和MT2A的下调是JPJDR影响CRC瘤微环境的关键机制.
更多相关视频
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
487
09:01Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
10.0K
相关概念视频
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
01:31Regulation of the Unfolded Protein Response
2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
01:45Positive Regulator Molecules
105.7K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
105.7K
01:01Feedback Loops
55.6K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
55.6K