通过小分子尺寸的固态相合成发现选择性β-分泌酶 (BACE-1) 抑制剂

相关实验视频

Updated: Jul 5, 2026

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
11:42

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Published on: May 15, 2012

24.6K

Khair Ullah1, Mikhlid H Almutairi2, Muhammad Naseer Abbas3

  • 1Department of Biochemistry, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan.

Current Alzheimer research
|February 11, 2025
PubMed
概括

研究人员确定21是β-分泌酶1 (BACE1) 的强有力的抑制剂,这是阿尔茨海默病 (AD) 发展中的关键酶. 这种非有毒的对未来针对AD治疗的体内研究有希望.

关键词:
一个H的NMR.阿尔茨海默病的疾病阿尔茨海默病的疾病.在ESI-MS中使用ESI-MS.在的中.在体外实验室内的合成的合成.固体相合成. 固体相合成.β-分泌酶 (BACE1) 是一种

更多相关视频

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.8K
Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms06:40

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

6.7K

相关概念视频

Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...