透皮药物输送系统:集成现代技术,用于增强治疗方法
Tanvi Kathuria1, Renu Saharan1, Sanchit Dhankhar2
1MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India- 133207.
Current drug safety
|February 11, 2025
概括
透皮药物递送系统 (TDDS) 的最新进展利用基于纳米的系统,微针和智能贴片来克服挑战. 这些创新提高了药物的溶解性,稳定性和皮肤透性,以改善治疗结果.
科学领域:
- 制药科学 制药科学
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 透皮药物输送系统 (TDDS) 提供一种非侵入性,患者友好的药物输送替代方案.
- 皮肤的屏障特性和药物透动态是通过皮肤治疗的关键考虑因素.
- 配方技术的进步旨在提高药物的溶解性,稳定性和皮肤透性.
研究的目的:
- 审查通过皮肤输送药物的最新发展和突破.
- 总结通过皮肤给药,强调皮肤屏障功能和透.
- 探索新的材料和方法,以增强药物特性,以通过皮肤使用.
主要方法:
- 关于TDDS近期创新的文献综述,包括纳米系统,微针和智能补丁.
- 讨论药物溶解性,稳定性和皮肤透性的挑战.
- 对治疗疼痛,心血管疾病和激素治疗中的应用而设计的透皮贴片的分析.
主要成果:
- 基于纳米的药物递送系统,微针阵列和智能贴片有效地解决了通过皮肤递送药物的挑战.
- 透皮贴片设计的当前进步显示出治疗应用的前景.
- 在疼痛管理,心血管疾病和激素治疗中突出了TDDS的有效例子.
结论:
- 在TDDS的技术进步是通过考虑法规,安全和患者合规来补充的.
- 本综述为研究人员,临床医生和制药专业人员提供了对透皮药物输送的全面了解.
- 未来开发出有效且对患者友好的TDDS可以提高治疗结果和患者的福祉.
相关概念视频
01:16Drug Delivery: Overview
273
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
273
01:22Drug Delivery: Miscellaneous Routes
305
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
305
01:18Drug Delivery: Enteral Route
372
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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01:29Drug Delivery: Parenteral Route
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
378
01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
367
01:24Cellular Membranes and Drug Transport
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Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
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