比菲多细菌 (Bifidobacterium) 在阿托皮性湿疹的发展中的Janus面:构成成熟的作用
Martin Depner1, Diana Hazard Taft2, Stefanie Peschel1
1Institute of Asthma and Allergy Prevention, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg, Germany.
概括
早期的肠道微生物群,特别是2个月的Bifidobacterium组成,与降低亚托皮性湿疹风险有关. 保护作用取决于年龄,强调及时的婴儿微生物干预.
科学领域:
- 微生物组研究的研究.
- 儿科过敏症儿童过敏症
- 肠道健康 肠道健康
背景情况:
- 婴儿肠道微生物群的组成在生命的第一年是动态的.
- 断奶会影响肠道细菌,如双菌,可能会影响生命早期的免疫发育.
- 环境因素可能与微生物刺激相互作用,影响疾病的发展轨迹.
研究的目的:
- 调查Bifidobacterium属在儿童早期亚托皮性湿疹的发展中的作用.
- 了解婴儿肠道微生物群与亚托皮性湿疹发病之间的关系.
主要方法:
- 使用16S rRNA amplicon测序分析PASTURE出生队列中的618名婴儿的便样本.
- 评估2个月和12个月的肠道细菌组成.
- 通过家长报告的医生诊断,在2岁时对亚托皮性湿疹的定义,症状模式通过潜伏类分析进行分类.
主要成果:
- 2个月后的Bifidobacterium组成显示出与阿托皮性湿疹和持续性皮疹的反向关联 (OR=0.68).
- 这种保护性关联在12个月后没有观察到,此时Bifidobacterium amplicon序列变异 (ASV) 的组成已经发生了变化.
- 2个月的有益ASVs具有保护作用 (OR=0.72),该保护作用减少了12个月 (OR=0.97).
结论:
- 在生命的第一年,Bifidobacterium的亚属组成发生了显著的变化.
- 抗阿托皮性湿疹的Bifidobacterium的保护作用取决于不同婴儿年龄的特定ASV成分.
- 针对婴儿微生物相互作用的干预措施的时间对于有效的预防策略至关重要.
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