协调的刺激和抑制电路控制不可预测的威胁引起的焦虑
Shuai-Wen Teng1, Xin-Rong Wang2, Zhong-Xiao Yao2
1Research Center for Basic Medical Sciences, Qilu Hospital of Shandong University, No.107 Wenhua Xi Road, Jinan, Shandong 250012, P.R. China; Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
Cell reports
|February 11, 2025
概括
研究人员确定了大脑中的神经回路,该回路会引发对不可预测威胁的焦虑. 这个电路涉及特定的神经元和通路,突出显示KCNQ3通道是焦虑症治疗的潜在目标.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 分子精神病学分子精神病学
背景情况:
- 焦虑症通常与对不可预测威胁的恐惧有关.
- 由不可预测的压力因素引起的焦虑背后的精确神经回路尚未完全理解.
- 识别这些循环对于开发有针对性的治疗干预措施至关重要.
研究的目的:
- 为了阐明负责由不可预测的威胁引发的焦虑的神经电路.
- 研究特定神经元群体和神经元通路在这种焦虑反应中的作用.
- 确定用于治疗焦虑障碍的分子标.
主要方法:
- 利用活动依赖的神经元标记来识别结末端 (vBNST) 的腹床核中的响应细胞.
- 研究了对vBNST GABAergic神经元的神经元输入,包括来自岛内皮层的谷氨酸神经元和来自杏仁体 (CeL) 侧核的体质神经元.
- 检查了vBNST细胞的投射到腹侧周水管灰色 (vlPAG) 和杏仁体的中间核.
- 评估了电压通道子家族Q成员3 (KCNQ3) 在vBNST神经元过活和焦虑行为中的作用.
主要成果:
- 肌末端 (vBNST) 的腹床核的GABAergic神经元被不可预测的威胁选择性地激活.
- 这种激活是由岛内皮层谷氨酸性神经元的刺激输入和CeL体静止素神经元的抑制输入调节的.
- vBNST神经元投射到杏仁体的vlPAG和中间核,分别驱动结和焦虑行为.
- KCNQ3通道对于vBNST GABAergic神经元的过度活动和随后的焦虑至关重要.
结论:
- 一个涉及vBNSTGABAergic神经元的前置抑制电路对于在不可预测的威胁和焦虑时的选择性激活至关重要.
- 该KCNQ3通道在调解由不可预测的压力引起的焦虑方面发挥着关键作用.
- KCNQ3代表了对由不可预测的压力因素引起的焦虑障碍的有希望的治疗标.
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