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TLR5信号导致树突细胞功能障碍,并协调免疫检查点治疗对卵巢癌的失败

Mitchell T McGinty1, Audrey M Putelo1, Sree H Kolli1

  • 1Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia.

Cancer immunology research
|February 11, 2025
PubMed
概括

收费类受体5 (TLR5) 信号阻碍了有效的卵巢癌免疫治疗. 阻断PD-L1/PD-1或CTLA4失败,因为TLR5信号损害了抗瘤T细胞,提供了一个新的治疗点.

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