一种光驱动的分子电机-多合体支持受控的细胞吸收
Camilla Pegoraro1, Ainoa Guinart2, Esther Masiá Sanchis1,3,4
1Príncipe Felipe Research Center, Polymer Therapeutics Lab., 46012 Valencia, Spain. iconejos@cipf.es.
Journal of materials chemistry. B
|February 11, 2025
概括
我们开发了一种新型的聚结合分子电机 (MM),在照射光线时增强细胞吸收和功能. 这种生物相容的P-MM系统显示出对光控制生物应用的前景.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 细胞生物学 细胞生物学
背景情况:
- 光驱动的分子电机 (MMs) 提供了对细胞功能的精确控制.
- 挑战包括生物相容性和溶解性差,限制它们的生物应用.
研究的目的:
- 开发一种生物相容和可溶性分子电机 (MM) 系统,以增强细胞反应.
- 为了研究新型P-MM结合体的光诱导行为和细胞相互作用.
主要方法:
- 通过点击化学合成了聚合MM (P-MM),将propargyl衍生MM与聚L-胺酸载体 (P) 连接起来.
- 在405nm辐射下评估了P-MM稳定性,旋转能力,细胞吸收,亚细胞向,细胞毒性和反应性氧物种的产生.
主要成果:
- 在405nm光照下,P-MM保留了MM的稳定性和旋转功能.
- 与对照组相比,光引起的形状变化显著增强了P-MM细胞吸收.
- P-MM显示出最小的细胞毒性和反应性氧物种的产生,表明良好的生物相容性.
结论:
- 合物P-MM成功地将分子电机功能与生物相容,向的纳米载体相结合.
- 光照射增强细胞反应,展示了对受控生物应用的潜力.
- 这种方法为先进的光响应性治疗和诊断策略铺平了道路.
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