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Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping
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在手术期间实施手术内高密度电皮质学.

Eline V Schaft1, Dongqing Sun1, Sem Hoogteijling1,2

  • 1Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Part of ERN EpiCARE, Utrecht, The Netherlands.

Epilepsia
|February 11, 2025
PubMed
概括

高密度手术内皮质电图 (HD-ioECoG) 通过捕捉局部尖和快波 (FRs) 提供了在手术中更详细的细节. 这种改进的检测可以改进外科手术策略,并可能提高患者的治疗结果.

关键词:
焦点发作发作是焦点发作.高频振荡的高频振荡.在手术内进行定制.脑下静脉EEG是什么意思

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科学领域:

  • 神经外科 神经外科
  • 发病学 (Epileptology) 是一个专业的学科.
  • 神经生理学 神经生理学

背景情况:

  • 标准手术使用低密度 (LD) 电极网,皮质覆盖范围有限.
  • 高密度 (HD) 网格在研究中表现有希望,但需要对手术进行临床评估.

研究的目的:

  • 评估HD网格在手术内外皮电图 (ioECoG) 中的临床实用性.
  • 为了确定HD-ioECoG是否通过检测局部活动和改善尖端发作的局部化来改变手术计划.

主要方法:

  • 分析了接受手术的HD-ioECoG (64个电极,5mm间距) 的患者.
  • 间点尖峰和高频振荡 (HFO),包括波纹和快波纹 (FR),在视觉上是显著的.
  • 使用格兰杰因果关系来评估尖端发病局部.

主要成果:

  • 在20名患者中,HD-ioECoG在6名患者中可能改变了手术计划.
  • 在切除区域检测到更多的FR,与发作自由度相关 (p < .001).
  • 有很大比例的焦点事件 (尖峰,波纹,FR) 发生在一个或两个通道上,可能会被LD网错过.

结论:

  • HD-ioECoG在临床上可用于指导手术.
  • HD-ioECoG提供了增强的细节来识别焦点事件,特别是FRs.
  • 通过HD-ioECoG更好地检测焦点事件和尖端发作,可以完善手术决策.