激素调节背景对体增强在增强对比度的乳房摄影中的激素调节
Noam Nissan1, Varadan Sevilimedu1, Jill Gluskin1
1From the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.
Radiology
|February 11, 2025
概括
荷尔蒙状况显著影响背景辅酶体增强 (BPE) 在对比增强乳房镜 (CEM) 上. 绝经前状态,哺乳期和激素替代疗法 (HRT) 会增加BPE,而他莫西芬治疗会降低它.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 背景帕伦基马增强 (BPE) 是乳房影像中的一个关键的成像生物标志物.
- 在MRI中,BPE的荷尔蒙调节得到了很好的研究,但在增强对比度的乳房造影 (CEM) 中,研究较少.
研究的目的:
- 评估各种荷尔蒙状态对通过CEM检测到的BPE的影响.
- 调查与更年期状态,哺乳期,激素替代疗法 (HRT) 和他莫西芬治疗相关的BPE变化.
主要方法:
- 从2012年12月到2024年1月,对507次CEM检查进行了回顾性分析.
- 患者被分为绝经前期,绝经后期,哺乳期,HRT和塔莫西芬子组.
- BPE被分级分级 (最小到标记) 并使用克鲁斯卡尔-沃利斯和奇平方/费舍尔精确测试进行分析.
主要成果:
- 绝经前和哺乳期患者的BPE明显高于绝经后患者.
- 与绝经后对照组相比,激素替代疗法 (HRT) 与BPE增加有关.
- 塔莫西芬治疗减少了BPE,而其停止导致了BPE的增加.
结论:
- 荷尔蒙因素,包括更年期状态,哺乳期,HRT和他莫西芬使用,显然会影响CEM中的BPE水平.
- 这些发现强调了在CEM研究中解释BPE时考虑荷尔蒙状况的重要性.
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