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Updated: May 28, 2025

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice
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在婴儿和儿童中使用布苏尔方剂量的新方法,该方法基于人口的药理动力学分析

Frank M Balis1,2, Elizabeth Rieger3, Nancy J Bunin3

  • 1Division of Oncology, Children's Hospital of Philadelphia and University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA. balisf@CHOP.edu.

Cancer chemotherapy and pharmacology
|February 11, 2025
PubMed
概括

种群的药理动力学建模细化了小儿病患者的布苏尔方剂量. 通过使用身体表面积 (BSA) 的新剂量策略,比传统的基于体重的剂量在显著更多的儿童中实现了治疗性布苏尔AUC.

关键词:
身体表面积 身体表面积 身体表面积身体重量 体重 体重布苏尔夫人 布苏尔夫人 布苏尔夫人剂量表 剂量表干细胞移植 干细胞移植治疗药物监测 治疗药物监测

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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii09:17

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