越南原生水牛的白色外套颜色归因于ASIP中的LINE1插入
Thuy Thanh Nguyen1,2, Quan Viet Le1, Van Huu Nguyen2
1Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
Tropical animal health and production
|February 11, 2025
概括
越南的白沼泽水牛的颜色源于ASIP基因中的LINE1插入. 这一遗传发现是改善该地区水牛生产力和耐热应激能力的关键.
科学领域:
- 动物遗传学动物遗传学
- 外套颜色的遗传学
- 牲畜基因组学 动物基因组学
背景情况:
- 沼泽水牛通常表现出深灰色的外套,但在亚洲存在白色变体,可能提供热应激优势.
- 雄鹿的白色外套颜色是经济上重要的特征,与适应性和生产力有关.
研究的目的:
- 为了确定越南原生水牛白外套颜色的遗传基础.
- 研究ASIP和TYR基因在白衣表型中的作用.
主要方法:
- 基因组DNA测序以识别基因变异.
- 在毛囊中的基因表达分析.
- 与以前报告的突变进行比较分析.
主要成果:
- 在ASIP基因中发现LINE1插入,仅在白色越南水牛中发现.
- 在白牛毛囊中观察到显著更高的ASIP基因表达.
- 在与白色表型相关的TYR基因中没有发现致病变体.
结论:
- 在ASIP基因中的LINE1插入是越南原生水牛白外套颜色的主要原因.
- 这一发现对于利用白衣特征提高越南水牛生产力和耐热度至关重要.
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