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Updated: Jul 29, 2026

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

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用人胚胎干细胞衍生的神经元应用于衰老建模和基因操纵的协议

Hui Zhang1, Shuhui Sun1, Juan Carlos Izpisua Belmonte2

  • 1Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

STAR protocols
|February 11, 2025
PubMed
概括

这项研究提出了使用人类胚胎干细胞衍生神经元来模拟神经元衰老的协议. 该方法允许使用小干扰RNA (siRNA) 进行基因沉默,以调查衰老机制和评估药物.

关键词:
细胞生物学 细胞生物学细胞分化的过程发育生物学是发展生物学.分子生物学分子生物学神经科学是一个神经科学.干细胞是干细胞.

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Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.