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Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...

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Updated: May 28, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

FarmGTEx TWAS服务器:一个交互式Web服务器,用于定制的TWAS分析.

Zhenyang Zhang¹, Zitao Chen¹, Jinyan Teng²

¹Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Genomics, proteomics & bioinformatics

|February 11, 2025

概括

FarmGTEx TWAS服务器简化了跨物种和组织的全转录组关联研究 (TWAS). 它将遗传变异与特征联系起来,揭示了猪和人类特征之间的共同遗传基础.

关键词:

交叉物种交叉物种交叉物种农场动物农场动物基因表达基因表达基因表达转录组范围的关联研究研究.网络服务器的Web服务器.

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Last Updated: May 28, 2025

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科学领域:

基因组学就是基因组学.
生物信息学是一种生物信息学.
进行比较基因组学.

背景情况:

全转录组关联研究 (TWAS) 对于将遗传位置与复杂特征联系起来至关重要.
现有的TWAS管道复杂,阻碍了跨物种遗传研究.
需要用户友好,多种类的平台来进行TWAS分析.

研究的目的:

引入农场动物基因型-组织表达 (FarmGTEx) TWAS服务器,一个多种类平台.
简化TWAS对不同组织和物种的分析.
为了促进物种之间的遗传发现的翻译.

主要方法:

开发了一个交互式TWAS服务器,集成人类,猪和牛的基因表达数据.
纳入基于基因型的基因表达预测和GWAS总结统计数据的归算.
启用了可自定义的TWAS分析,功能注释和可视化.

主要成果:

服务器为跨物种和组织的数千个基因提供预测模型.
确定了479203个人类,1208个牛和657个猪组织-基因-特征的关联.
验证了ABCD4基因与猪乳数的关联,并发现了猪背部脂肪和人类特征 (例如BMI) 之间的共同遗传联系.

结论:

FarmGTEx TWAS服务器为跨物种TWAS提供了一个全面和可访问的资源.
该平台有助于发现潜在特征的保存遗传机制.
未来的扩张将包括更多的物种,增强比较遗传研究.