重复的压力会逐渐损害听觉处理和感知能力
Ghattas Bisharat1,2, Ekaterina Kaganovski1,2, Hila Sapir1,2
1Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
PLoS biology
|February 11, 2025
概括
重复的压力改变了大脑处理声音的方式,减少了对大声的感知. 这种对感官处理的影响随着时间的推移而演变,影响行为超出了带有情感的刺激.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 压力研究 压力研究
背景情况:
- 重复的压力是精神和感官疾病的危险因素.
- 在这些疾病中,感知异常是常见的,但潜在的机制尚不清楚.
- 压力对感官处理的影响,特别是对中性刺激的影响,尚不清楚.
研究的目的:
- 研究重复性压力如何调节成年小鼠的听觉处理和感知.
- 为了确定压力是否会影响中性声音的处理.
- 探索压力诱导的感知变化的时间动态.
主要方法:
- 在小鼠中诱导重复性压力.
- 皮层神经活动的纵向测量.
- 以听觉为指导的行为任务来评估感知.
主要成果:
- 重复的压力改变了声音处理,增加了自发的皮质活动.
- 压力抑制了金字塔细胞和蛋白 (PV) 细胞中声音唤起的反应.
- 压力加剧了体静止素 (SST) 细胞的声音唤起反应,导致大声感知减少.
- 压力对感知的影响随着时间的推移逐渐发展.
结论:
- 重复的压力显著改变听觉处理和感知,挑战了压力只会影响情绪充满刺激的观念.
- 这些发现表明,慢性压力会影响感官知觉的神经机制.
- 强调了压力对感知影响的动态性和时间依赖性.
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