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儿童大脑形态测量在儿童的持续缩和追赶增长的孩子
Beena Koshy1, Vedha Viyas Thilagarajan1,2, Samuel Berkins3
1Developmental Paediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
PloS one
|February 11, 2025
概括
儿童发育迟缓会影响大脑发育,影响大脑总体体积和特定区域,如脑后皮层. 持续的发育迟缓,即使有追赶成长,也与儿童大脑形态的减少有关.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 幼儿发育迟缓影响全球1.5亿名儿童,可能会阻碍终身的人类潜力.
- 关于缩和随后的追赶增长如何影响大脑结构的数据有限.
研究的目的:
- 为了研究持续的儿童发育迟缓和追赶成长对9岁大脑形态学的影响.
- 为了在南印度出生队伍中比较不同发育阻碍轨迹的大脑体积.
主要方法:
- 在一个基于社区的出生队列研究中,利用了178名儿童 (年龄为9.54岁) 的MRI扫描.
- 孩子们被分为"从来没有迟"",迟然后被抓住"和"总是迟"的群体.
- 使用FreeSurfer量化大脑体积,并使用ANOVA分析差异,控制年龄和性别.
主要成果:
- 从从未缩的群体到始终缩的群体观察到总大脑体积,皮下区域,小脑白质和大脑体的下降趋势.
- 与从未缩的儿童相比,总是缩的儿童在横向尾皮层,尾皮层,尾状皮层和丘脑皮层的体积明显较低.
结论:
- 这项研究提供了第一个神经成像证据,将持续的儿童发育迟缓与大脑体积受损联系起来.
- 研究结果表明,大脑总体体积,皮下结构,网络中心 (大脑体,基底,大脑,小脑) 和视觉处理区域的缺陷.
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