增加风险状况的成年人中COVID-19的严重结果:基于人口的观察性研究
Scott Dryden-Peterson1,2,3, Andy Kim1, Ellen C Caniglia4
1Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
患有多种疾病的个人面临重大COVID-19风险,即使有先前的免疫力. 抗病毒治疗为这些高风险患者提供了巨大的好处,减少了严重的结果.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 了解免疫群体中严重的COVID-19结果对于及时诊断和治疗至关重要.
- 缺乏当前的风险估计阻碍了对弱势个体的护理.
研究的目的:
- 为了评估不同并发症水平的严重COVID-19结果.
- 评估并发症对风险的影响,包括在没有记录感染的患者中.
主要方法:
- 使用电子健康记录进行基于人口的队列研究.
- 采用方法来解决COVID-19病例文档中的选择偏见.
- 分析了美国东北部卫生系统 (2022年6月至12月) 患有风险增加的成年人的数据.
主要成果:
- 在患有风险增加的患者中,1.3%的患者经历了严重的结果 (住院治疗或死亡).
- 患有多重并发症 (MASS 4+) 或严重免疫性损害的患者有2.3%的严重结局风险,占死亡人数的81%.
- 抗病毒治疗显示降低了风险,特别是在具有较高并发病率得分的人群中.
结论:
- 患有多种疾病的个人面临严重的COVID-19结果的重大风险.
- 抗病毒治疗对具有多种并发性疾病的高风险个体有益.
- 在这个人群中准确估计COVID-19病例仍然是一个挑战.
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