不同胰岛素抵抗指数与老年人骨健康之间的关联
Tianjie Lai1, Zhihao Su2, Rui Chen1
1Department of Spine Surgery, The Affiliated Yuebei People's Hospital of Shantou University Medical College, Shaoguan, Guangdong, P.R. China.
PloS one
|February 11, 2025
概括
甘油三糖指数 (TyG) 和相关标志物显示,与骨密度有积极联系,与50岁以上成年人骨质疏松症风险有负面联系. 这些发现表明,胰岛素抵抗与骨健康之间存在联系.
科学领域:
- 代谢健康 代谢健康
- 骨的新陈代谢 骨的新陈代谢
- 老年医学 老年医学
背景情况:
- 甘油三糖 (TyG) 指数及其衍生物 (TyG-BMI,TyG-WC,TyG-WHtR) 是已确立的代谢疾病指标,特别是胰岛素抵抗 (IR).
- 关于TyG指数及其相关标志物与骨矿物质密度 (BMD),骨质疏松症和骨质疏松症的关联,研究有限.
研究的目的:
- 调查TyG指数及其相关指数与50岁及以上成年人骨质疏松症,骨质疏松症和骨质疏松症之间的关系.
- 通过使用可访问的代谢标志物,探索胰岛素抵抗和骨健康之间的潜在联系.
主要方法:
- 这是一项横截面研究,使用了来自国家健康和营养检查调查 (2007-2010年和2013-2014年) 的1,303名成年人 (≥50岁) 的数据.
- 进行了多变量调整的线性和逻辑回归分析.
- 使用趋势分析和受限立方线分析来评估剂量反应关系和非线性关联.
- 进行了敏感性分析,以证实研究结果的可靠性.
主要成果:
- 在TyG指数及其相关指数与大腿部部,腰椎和全部的BMD之间观察到显著的正相关性.
- 在这些指数和骨质疏松症/骨质疏松症的患病率之间发现了显著的负相关性.
- 通过趋势和灵敏度分析确定了非线性关系和确认的关联.
结论:
- 泰格指数及其相关指数与老年人骨髓损伤和骨质疏松症风险有显著的关联.
- 这些发现凸显了胰岛素抵抗与骨健康受损之间的潜在联系.
- TyG指数和相关标记可以作为诊断,预防和骨质疏松症管理的宝贵工具.
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