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Updated: May 28, 2025

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
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宿主-客体化学介导的复杂糖脂的生物仿真化学合成

Yuan Ma1,2, Yating Liu1, Chang Cao3

  • 1State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Journal of the American Chemical Society
|February 11, 2025
PubMed
概括

一种新的仿生化酶方法有效合成多种复杂的糖脂 (GSL). 这种方法利用宿主-客体化学和甲基-β-环氧来提高GSL的溶解度,从而使生物医学研究的GSL图书馆得以建立.

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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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