脑卒中后的行动减缓随着任务复杂度的增加而增加,并且与更广泛的脑部招募有关
Olivier Godefroy1, Sandrine Canaple2, Pierre-Andrea Cervellera1
1Departments of Neurology, Amiens University Hospital, Amiens, France; Laboratories of Functional Neurosciences, (UR 4559), Jules Verne University of Picardie, Amiens, France.
概括
脑卒中患者表现出较慢的行动速度,随着任务的复杂性而恶化. 更复杂的测试对与中风相关的减速更为敏感,反映出大脑网络的参与和对病变的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 神经心理学 神经心理学
背景情况:
- 脑卒中后认知减速的机制尚未得到充分理解.
- 在中风幸存者中,动作速度经常受到损害.
- 了解影响减速的因素对于康复至关重要.
研究的目的:
- 描述认知测试复杂性与中风中行动速度减慢之间的关系.
- 调查测试灵敏度,大脑区域招募和病变负载与复杂性效应的关系.
- 探索个体减速特征和神经成像标志物之间的相关性.
主要方法:
- 从GRECogVASC研究中分析了371名中风患者和581名对照人群.
- 评估使用八个时间有限的测试,复杂度各不相同 (例如,手指敲击,反应时间,Trail Making Test,流利性测试).
- 作用速度,测试灵敏度和病变体积与神经成像数据的相关性 (受损的口腔,白质超强度,大脑部分).
主要成果:
- 与对照组相比,中风患者的作用速度显著减慢 (p < .0001).
- 随着测试复杂度的增加,减速显著增加 (每步7.7%,p < .0001).
- 更复杂的测试显示对中风影响的敏感性更高,与更大的招募大脑网络和病变体积相关.
结论:
- 脑卒中诱导的减速是一般处理速度缺陷和复杂任务的放大减速的组合.
- 在中风中测试灵敏度反映了参与的神经网络的大小和脆弱性.
- 研究结果提供了关于动作速度的神经组织的见解,以及它因中风而受到破坏的见解.
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