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长期暴露于柴油发动机的废气和气道细菌组的改变

Menghui Jiang¹, Yongwei Yan², Tao Wang³

¹School of Public Health, Qingdao University, Qingdao, Shandong, China.

Ecotoxicology and environmental safety

|February 11, 2025

概括

柴油发动机废气 (DEE) 暴露会改变工人呼吸道细菌,影响肺功能. 特定的细菌变化与减少的强迫生命能力 (FVC) 和1秒内强迫呼吸量 (FEV1) 相相关.

科学领域:

环境健康环境健康
微生物组研究微生物组研究
职业医学职业医学是专业的.

背景情况:

柴油发动机废气 (DEE) 对公众健康构成重大风险,特别是对呼吸系统健康.
呼吸道微生物组,DEE暴露和呼吸道结果之间的关系还不清楚.

研究的目的:

为了识别暴露于柴油工人的呼吸道细菌特征.
评估这种特征与呼吸系统健康指标之间的相关性.

主要方法:

从54名暴露于柴油油的工人和52名未暴露的对照组中采集了诱导性唾液样本.
进行了肺功能测试 (FVC,FEV1).
进行了细菌社区分析.

主要成果:

与对照组相比,暴露于柴油的工人表现出明显较低的FVC和FEV1.
在暴露和未暴露组之间观察到明显的呼吸道细菌特征,在Prevotella nanceiensis,Prevotella shahii,Aggregatibacter segnis和Lachnoanaerobaculum umeaense中发现了显著的差异.
暴露的个体具有较少复杂的气道细菌组网络和较少的基石物种.
特定的细菌物种与气道巨细胞 (CCAM),球状细胞蛋白 (CC16),FVC和FEV1.1中的碳含量相关.

结论:

柴油发动机排气暴露显著改变了职业人口的呼吸道细菌特征.
这些变化与肺功能受损有关.
特定的气道细菌可以作为DEE诱导的呼吸系统影响的生物标志物.

关键词:

呼吸道细菌体呼吸道细菌体柴油发动机的废气排放情况呼吸系统健康呼吸系统健康

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