耳部特异性神经可塑性,用于单侧耳聋患者的声音定位
Leeseul Shim1, Jahee Kim2, Gibbeum Kim3
1Laboratory of Brain & Cognitive Sciences for Convergence Medicine, Hallym University College of Medicine, Anyang, Gyeonggi-do 14068, Republic of Korea; Ear and Interaction Center, Doheun Institute for Digital Innovation in Medicine (D.I.D.I.M.), Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Republic of Korea.
Hearing research
|February 11, 2025
概括
单侧耳聋 (SSD) 改变了听觉皮层的活动,影响了声音的定位. 增强的皮质注意力,特别是在右听力皮层,有助于SSD患者的空间听力.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 神经成像是一种神经成像.
背景情况:
- 单侧耳聋 (SSD) 导致皮质可塑性,听力皮质活动增加,与受损耳朵相反.
- 将神经可塑性与双耳处理和SSD中的听觉局部化缺陷联系在一起的精确神经机制尚未完全理解.
- 之前的研究强调了听觉皮层反应的改变,但缺乏对网络参与和性能相关性的详细分析.
研究的目的:
- 为了研究神经可塑性变化和听觉局部化能力在语后单面聋症之间的关系.
- 为了比较左侧SSD,右侧SSD和正常听力控制的个体之间的听觉定位期间的皮质网络活动.
- 为了确定听觉定位表现的神经相关性及其与SSD持续时间的关联.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估在听觉定位任务期间的大脑活动.
- 参与者包括17个左侧SSD,18个右侧SSD和13个正常听力控制 (也用模拟的单耳听力进行测试).
- 进行了皮层网络分析和相关性分析,以将神经活动与本地化性能和SSD持续时间联系起来.
主要成果:
- 扩展的单侧聋与调制的听觉皮层反应有关,特别是在右侧主要听觉皮层.
- 后部上回形和环膜-状网络显示出与改善的听觉定位性能有显著联系.
- 听觉皮层的响应横向性在SSD组和对照组之间有所不同,这表明了自适应的神经重组.
结论:
- 皮层注意力资源在单侧聋个体中维持听觉空间行为方面发挥着至关重要的作用.
- 听力皮层中的神经可塑性适应,特别是右半球,对于补偿听力损失至关重要.
- 研究结果强调了注意力网络对SSD听觉功能的重要性,特别是当左耳受到影响时.
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