从食品容器释放的微塑料的亚细胞毒性评估
1School of Energy and Environment and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, China.
Journal of hazardous materials
|February 11, 2025
概括
塑料食品容器在加热或冷却时会释放微塑料 (MP),而冷容器则会释放更多的微塑料. 这些MPs可以伤害细胞,表明亚细胞反应是毒性比细胞活力更敏感的指标.
科学领域:
- 环境科学 环境科学
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 塑料食品容器在食品包装和储存方面无处不在.
- 人们对这些容器在不同温度下释放的微塑料 (MP) 存在担忧.
- 调查MP释放和细胞毒性对于食品安全至关重要.
研究的目的:
- 在冷却和加热过程中,研究食品容器中微塑料的释放情况.
- 用Caco-2细胞评估释放的微塑料的体外细胞毒性.
- 为了评估细胞反应和微塑料的吸收.
主要方法:
- 从聚烯 (PP) 和聚烯 (PS) 容器中释放的量化微塑料颗粒.
- 通过细胞活力测定评估细胞毒性.
- 使用尼罗河红色染色和共聚焦显微镜可视化细胞吸收.
- 监测细胞器官和酶活动的变化.
主要成果:
- 容器释放了每一个容器10万26万颗粒 (0.10.3毫克).
- 冷食品容器释放出更多更小的塑料颗粒.
- 微塑料诱导了细胞活力的剂量依赖性下降,特别是在冷容器中.
- 从冷条件下的聚乙烯容器显示出显著的细胞反应 (溶酶体变化,ROS形成).
- 亚细胞反应是MP毒性比细胞活力更敏感的指标.
结论:
- 微塑料在温度变化下从PP和PS食品容器中释放.
- 释放的微塑料表现出剂量依赖的细胞毒性.
- 亚细胞变化是微塑料暴露的敏感指标.
- 需要进一步的研究和法规来解决食品包装中的微塑料风险.
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