非致命自我伤害与癌症诊断后的生存之间的关联:基于人口的比较队列研究
Antoine Eskander1,2,3,4,5, Rinku Sutradhar2,3,4, Elie Isenberg-Grzeda6,7
1Division of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Journal of the National Comprehensive Cancer Network : JNCCN
|February 11, 2025
概括
癌症患者的非致命自我伤害 (NFSI) 显著降低了整体存活率. 识别和治疗癌症患者的痛苦是减轻NFSI风险和改善结果的关键.
科学领域:
- 在瘤学瘤学.
- 心理健康 心理健康
- 公共卫生 公共卫生
背景情况:
- 非致命自我伤害 (NFSI) 是癌症诊断后的一个严重的心理健康问题.
- 关于NFSI对患者结局的影响,特别是整体存活率 (OS),仍然基本上是未知的.
- 了解NFSI在癌症护理中的负担对于改善患者管理至关重要.
研究的目的:
- 研究癌症诊断后NFSI与随后的整体存活率 (OS) 之间的关联.
- 量化NFSI事件对癌症患者死亡风险的影响.
- 突出NFSI作为癌症相关痛苦的潜在指标.
主要方法:
- 一项以人口为基础的回顾性队列研究使用了相关的行政医疗保健数据.
- 包括2007年至2019年间被诊断患有癌症的患者.
- 使用扩展的Cox多变量模型分析NFSI被视为时间变化的暴露,OS是主要结果.
主要成果:
- 在806,910名癌症患者中,0.31%的患者经历了NFSI,诊断后的中位数为29个月.
- 患有NFSI的患者表现出明显较低的OS (调整后HR,1.73).
- 每个额外的NFSI事件都与死亡风险增加有关 (调整后HR,1.17).
结论:
- 癌症诊断后的NFSI独立地与较差的整体存活率有关.
- 作为一个关键事件,NFSI强调了癌症相关痛苦的早期识别和干预的必要性.
- 对于患有NFSI风险的癌症患者,积极的心理健康支持至关重要.
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