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Updated: May 28, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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显著的乙载体蛋白对接点有助于调解A型和B型模块化多基基酸合成酶基降解酶的相反的立体选择性

Katherine A Ray1, Sally N Lin1, Adrian T Keatinge-Clay1

  • 1Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.

Biochemistry
|February 11, 2025
PubMed
概括

模块化聚基酸合成酶 (PKSs) 使用乙载体蛋白 (ACPs) 来提供中间体给缩酶 (KRs). 在KRs上,特定的对接点对于处理这些中间体至关重要,影响最终的多基化物结构.

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