移植受体中由神秘物种引起的侵袭性阿斯伯吉洛斯病:一篇综述
Muneyoshi Kimura1,2, Shahid Husain1
1Transplant Infectious Diseases, Ajmera Transplant Program, University Health Network, Toronto, Ontario, M5G 2N2, Canada.
Medical mycology
|February 11, 2025
概括
来自神秘的阿斯伯吉勒斯物种的侵入性阿斯伯吉勒斯病 (IA) 对移植受体构成严重威胁. 新的诊断和抗真菌策略对于管理这些具有挑战性的感染至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 移植医学 移植医学 移植医学
背景情况:
- 侵入性阿斯伯吉洛症 (IA) 是固体器官和血造干细胞移植接受者的常见真菌感染.
- 在这些免疫受损人群中,由于神秘的Aspergillus物种引起的IA的临床和微生物特征仍然不太清楚.
研究的目的:
- 在移植受体中定义由神秘的阿斯伯吉卢斯物种引起的IA的临床和微生物特征.
- 审查诊断方法和抗真菌敏感性模式,以指导治疗策略.
主要方法:
- 追溯分析报告的IA病例由神秘的阿斯伯吉卢斯物种引起.
- 检查诊断方法,包括矩阵辅助激光消化离子化-飞行质谱的时间.
- 对抗真菌敏感性数据和治疗结果的分析.
主要成果:
- 阿斯珀吉勒斯·卡利多斯托斯,A. lentulus,A. tubingensis和A. udagawae是最常见的被发现的神秘物种.
- 在24例有详细信息的病例中,13例发生了抗真菌突破性感染.
- 12周死亡率很高,在特定物种和整体中约为43-46%.
结论:
- 隐秘的阿斯伯吉卢斯物种在移植受体中构成重大挑战,经常呈现出高死亡率.
- 像MALDI-TOF MS这样的先进诊断对于准确的物种识别至关重要.
- 根据敏感性概况,推量身定制的抗真菌疗法,可能包括新的药物.
相关概念视频
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Fungal Phylum Ascomycota
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...


