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通过热挤出和喷雾干燥制备的无形固体分散物的稳定性和再结晶

Dominik Martynek1, Luděk Ridvan2, Mia Sivén3

  • 1Department of Chemical Engineering, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Dejvice, Czech Republic; Zentiva, k.s., Ukabelovny 130, 10237 Prague 10, Czech Republic.

International journal of pharmaceutics
|February 11, 2025
PubMed
概括

喷雾干燥和热挤出产生无形固体分散 (ASD). 热挤出提供了更好的稳定性,而喷雾干燥提高了溶解率,PVP K30的性能优于HPMC E5.5.

关键词:
无形固体分散的分散.解散 解散 解散 解散热挤出方式再结晶化 再结晶化喷雾干燥 喷雾干燥稳定的稳定性 稳定的稳定性

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